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KMID : 0382619910110010411
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Hanyang Journal of Medicine
1991 Volume.11 No. 1 p.411 ~ p.419
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Morphologic Effects of Sodium Hyaluronate on Rabbit Conjunctival Epithelium
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Abstract
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This study was carried out whether sodium hyaluronate may affect the mucous layer of the tear film and surface layer of the conjunctival epithelium by histochemical electron microscopy. Sodium hyaluronate was injected into the subconjunctival tissue of five rabbits twice a week for 10 weeks. The excised specimen was treated with ruthenium red to enhance the presence of glycosaminoflycans of the surface layer of the conjunctiva.
From the histochemcial electron microscopic point of view, sodium hyaluronate did not Improve the content of glycosaminoglycans density in the tear film over the surface of the conjunctival ?? In addition, there was no evidence of epithelial lesions such as desquamation. ?? However, the muccus layer was Intermingled with secretory granules of goblet cell with the mucus layer spread over glycocalyx.
The results of this study indicate that sodium hyaluronate injected into the sub conjunctival layer has little effect on the glycosaminoglycans density over the con-junctilral epithelium in rabbit.
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